... circumstances they may provoke a biopsy.
Chapter 086. Breast Cancer
(Part 3)
The Palpable Breast Mass
Women should be strongly encouraged to examine their breasts monthly. A
potentially flawed ...
during the follicular phase of the menstrual cycle. Days 5–7 of the cycle are the
best time for breast examination. A dominant mass in a postmenopausal woman or
a dominant m...
... Chapter 086. Breast Cancer
(Part 10)
Endocrine Therapy
Normal breast tissue is estrogen-dependent. Both primary and metastatic
breast cancer may retain this phenotype. ... metastatic
breast cancer may retain this phenotype. The best means of ascertaining whether a
breast cancer is hormone-dependent is through analysis of estrogen and
progesterone receptor levels...
... full-term pregnancy.
Chapter 086. Breast Cancer
(Part 1)
Harrison's Internal Medicine > Chapter 86. Breast Cancer
Breast Cancer: Introduction
Breast cancer is a malignant proliferation ... these genes play in inherited forms of
breast cancer may be their role in sporadic breast cancer. The p53 mutation is
present in nearly 40% of human breast can...
... Chapter 086. Breast Cancer
(Part 4)
If a nonpalpable mammographic lesion has a low index of suspicion,
mammographic ... f/u, follow-up.
Breast Masses in the Pregnant or Lactating Woman
continue to believe that screening conveys substantial benefit. Furthermore, the
profound drop in breast cancer mortality seen ... diagnosis, and women who have
had a biopsy with beni...
...
sentinal lymph node dissection but not clinically apparent
Chapter 086. Breast Cancer
(Part 5)
Staging
Correct staging of breast cancer patients is of extraordinary importance. Not
only ... Used with permission of the American Joint Committee on Cancer
(AJCC), Chicago, Illinois. The original sour
ce for this material is the AJCC
Cancer Staging Manual, Sixth Edition (...
...
appropriate systemic regimen.
Prognostic Variables
Chapter 086. Breast Cancer
(Part 6)
Breast Cancer: Treatment
Primary Breast Cancer
Breast- conserving treatments, consisting of the removal ... therapy after local management of breast cancer
substantially improves survival. More than one-third of the women who would
otherwise die of metastatic breast cancer...
...
IIIA 47
IIIB 44
IV 14
Source: Modified from data of the National Cancer Institute—
Surveillance,
Epidemiology, and End Results (SEER).
Estrogen and progesterone
... although small advantages for doxorubicin-containing
regimens are usually seen.
Chapter 086. Breast Cancer
(Part 8)
Table 86-3 Suggested Approaches to Adjuvant Therapy
Age Group
Lymp
h
...
liver) metastases each account for approximately one-third of sites of initial
Chapter 086. Breast Cancer
(Part 9)
One approach—so-called neoadjuvant chemotherapy—involves the
administration ...
misdiagnosed and treated as though they had metastatic breast cancer or even
second malignancies such as multiple myeloma thought to be recurrent breast
cancer. This is a cata...
... disease-free survival in about 30–50% of patients.
Breast Cancer Prevention
Women who have one breast cancer are at risk of developing a contralateral
breast cancer at a rate of approximately 0.5% per ... disease.
Stage III Breast Cancer
Between 10 and 25% of patients present with so-called locally advanced, or
stage III, breast cancer at diagnosis. Many of these c...