... details of these tests and how they are applied in individual disorders, see Chaps. 98, 99, 100, 101, and 102. Definition and Classification of Anemia Initial Classification of Anemia The functional ... classification of anemia has three major categories. These are: (1) marrow production defects (hypoproliferation), (2) red cell maturation defects (ineffective erythropoiesis ), and (3) decreased ... below) and a reticulocyte production index < 2 will demonstrate an M/E ratio of 2 or 3:1. In contrast, patients with hemolytic disease and a production index > 3...