... opening of the nonselective, highly conductive PTP in the mitochon-drial IM [39]. The exact molecular composition of the PTP remains unclear. When MPT occurs, MPcollapses, leading to the failure of ... critical step in the activation of mitochondria-dependent apoptosis [12], the assembly of the apoptosome. Upon formation of this complex, caspase-9 acquires the ability to trigger the processing ... decreasing the activity of caspase-3 in the three cell lines.Effect of HSS knockdown on CCCP-inducedapoptosisTo further elucidate the functional role of HSS inCCCP-induced apoptosis, the expression...