... numerous regulatory proteins including CD59, clus-terin, vitronectin, C1-inhibitor, C4-binding protein,decay-activating factor, and Factor H, which inhibit differ-ent steps in the complement ... systemic admin-istration of the excitotoxin kainic acid [108,109], orinjection of the neurotoxin colchicine into the dorsal hip-pocampus [109]. Surgical transection of the perforantpathway increased ... activating complement [72]. In contrast to therobust staining of complement proteins in matureplaques, immunoreactivity to these proteins in diffuseplaques has generally been below the level of detection,though...