... paromomycin,neomycin, gentamicin, and kanamycin at the A-site of12S rRNA [14]. Thus, the administration of aminoglyco-side s can induce or worsen hearing loss in these subjectscarrying the ... his-tory of exposure to aminoglycosides including gentami-cin, streptomycin and kanamycin, accounting for 22.3%cases of hearing loss in this cohort. These subjects, dueto infections or other illness, ... suggesting an important role in the initiation of mitochondrial protein synthesis [31].Furthermore, the frequency of mutations at position 961including 961insC and 961T > C was 2.27% in thispediatric...