... could result in varyingamounts of photobleaching leading to reduced produc-tion of ROS at high concentrations.4.3 Cellular responses to PDT induced damageIt is intriguing that the effects of ... tomicrotubular (MT) network since it has been shown thatMT disruption is involved in apoptosis [50,51]. Depo-lymerization of tubulin may be caused by an increase in PDT induced intracellular calcium ... Photodamage induced by Zinc(II)-phthalocyanine to microtubules, actin, alpha-actinin and keratin of HeLa cells. Photochem Photobiol 2001, 73:283-289.30. Gantchev TG, Gowans BJ, Hunting DJ, Wagner...