... analysis and interpretation, and drafted the manuscript. PP and LG participated inacquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript. LG, JV, and ... SQ participated in acquiring clinicalsamples and follow-up clinical information. MSC participated in study design and coordination, data analysis and interpretation and final writing of themanuscript. ... specificity of the methylated candidates), and also with previousreports describing methylation for some of the candi-dates under study, such as PRDM2 [32], RUNX3[35,36], SFRP4 and SFRP5 [36],...