... production in murine brains within 24hours. In contrast, the intracerebral injection of murineIntracerebral IL-18 concentrations in mice, as determined by ELISA in murine brain homogenates (n = 10 animals ... corresponds to the time-point of maximalextent of intracerebral inflammation in the model of CHIused in this study [17].For assessment of intracerebral IL-18 levels, the murinebrains were immediately ... effects of pro-inflammatorymediators, depending on the kinetic of their expressionand posttraumatic regulation in the injured brain[3,12,13]. However, the TNF -dependent regulation of IL-18 in...