... figure 3].In most forms of CKD, the number of interstitial myofi-broblasts is increased, and strongly correlates with thedegree of interstitial fibrosis [77,78]. Activated myofibro-blasts constitute ... theprogression of renal disease [79,80]. Myofibroblasts are themain source of excessive ECM in fibrotic nephropathies[51]. Myofi broblasts may be originated by trans-differen-tiation of fibroblasts, ... simple method of stimating progression of chronic renal failure. Lancet 1976, 2:1326-1328.2. Remuzzi G, Benigni A, Remuzzi A: Mechanisms of progression andregression of renal lesions of chronic...