... few of the donors were in the first day of the disease. Others were in the second or third day of the disease.""Then we proceeded to transfer the virus obtainedfrom cases of the disease; ... also the mucous membranes of the throat."Then they mixed all the "stuff" together and sprayed 1 cc of the mixture in each of the nostrils of 10 volunteers, and"into the throat, ... demonstrable seasonal variations,population variations, and a mechanism of action.To make sense of influenza's epidemiology, we reviseHope-Simpson theory, hypothesizing marked variation in the infectivity...