... [2,5,7].The RNA binding motif protein 3, RBM3, is a glycinerich protein containing a RNA-recognition motif (RRM)through which it binds to both to DNA and RNA [8].Proteins containing specific RRMs ... implicated in cisplatin resistance, i.e.decreased drug uptake, insufficient DNA-binding of thedrug, increased DNA-repair of cisplatin adducts and fail-ure of induction of apoptosis, reviewed in [2,5,7].The ... distribution and apoptosis in A2780 and A2780-Cp70cell lines. (A) Immunocytochemical staining and (B) immunoblotting of RBM3 showing substantially lower RBM3 protein expression in thecisplatin-resistant...