... altering bind-ing properties of aminoglycosides such as paromomycin,neomycin, gentamicin, and kanamycin at the A-site of 12S rRNA [14]. Thus, the administration of aminoglyco-side s can induce or ... screening of 12SrRNA gene in a cohort of 440 hearing-impaired HanChinese pediatric subjects from two otology clinics atNingbo and Wenzhou, Zhejiang Province, China. Muta-tional analysis of 12S ... 7.5% cases of this Chinese clinicalpopulation, while incidences of this mutation were1.76% and 3.96% in two large cohorts of hearingimpaired pediatric Han Chinese subjects from schools of deaf...