... as kinase-insert domain-containing receptor(KDR) [2]. In animal models of chronic ischemia, manoeuvres thatincrease VEGF levels by intramuscular injection or vascu-lar infusion of adenoviral ... proliferation andmigration in response to angiogenic stimuli, in particularhypoxia. Arteriogenesis is, instead, a result of growth andpositive remodeling of pre-existing vessels, forming largerconduits ... interplay duringconditions of chronic ischemia and can be modulated byseveral growth factors, transcription factors and cytokines[3,4]. In particular, the main regulator of neovascularization in adult...