... systemic admin-istration of the excitotoxin kainic acid [108,109], orinjection of the neurotoxin colchicine into the dorsal hip-pocampus [109]. Surgical transection of the perforantpathway ... [52], and the increased neuronal loss in the APP/sCrry mouse may bedue to decreased production of C3a as well as the opsonin, C3b. However, whether inhibition of comple-ment activation in the AD ... activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton. Neuroscience 1996, 73:1091-1107.47. Yao J, Harvath L, Gilert DL, Colton CA: Chemotaxis by a CNSmacrophage, the...