... depending on the kinetic of their expression and posttraumatic regulation in the injured brain[3,12,13]. However, the TNF-dependent regulation of IL-18 in the injured brain has not yet been investigated. ... IL-18 production in murine brains within 24hours. In contrast, the intracerebral injection of murineIntracerebral IL-18 concentrations in mice, as determined by ELISA in murine brain homogenates ... ES, and PFS were responsible for con-ception and planning of the experiments, as well as for performing the animal experiments, collection of the human cerebrospinal fluid samples and cytokine...