... AccessResearch Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemiaManu Jatana1, Shailendra Giri1, Mubeen A Ansari1, Chinnasamy ... Gilg AG, Sekhon C, Singh I, SinghAK: Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci ... injury in rats via down-regulation of theinflammatory mediators NF-κB and iNOS. Thus, inhibit-ing the 5-LOX /NF-κB pathway holds therapeutic potentialto attenuate inflammation-mediated brain...