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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc

báo cáo hóa học:

báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc

... p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCsYasuhisa Yamashita1, ... that the expression of EGF-like factor and TACE /ADAM17 in cumulus cells was induced by aPKA-, p38 MAPK- and ERK1/2- dependent mechanism during in vitro maturation of porcine COCs. The intracel-lular ... mechanism of induction of the expression of EGF-like factor and TACE /ADAM17 further induce EGF-like factor and Tace /Adam17 mRNA expressions in cumulus cells via ERK1/2 activation. Thereby, the ERK1/2...
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báo cáo hóa học:" A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis" potx

... the expression of the vacciniavirus I7L gene is under the control of the tetracycline operator/repressor system. In the absence of I7L expression, processing of the major VV core proteins is inhibited ... for the processing of p4a, withprocessing in each of the wild type virus lanes, repressedprocessing with the mutant in the absence of TET and increased processing in the presence of TET (data ... TREx-293 cells were infected with vtetOI7L at an MOI of 1 in thepresence or absence of TET and harvested 24 h later. In thepresence of TET, cells contained a variety of both imma-ture and mature forms...
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báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc

... unpublishedobservations). This pharmacodynamic effect on B cells is particularly interesting in light of increasing evidence thatB cells can regulate tumor cellular immunity. Recent find-ings in murine models ... theinclusion of TLR9 stimulation is important for optimal activation of naïve B cells, a finding of particular impor-tance for patients with advanced cancer in whom naïve B cells dominate the peripheral ... tolerogenic B cells in mice can be converted tostimulatory cells following CD40-mediated activation [21], our findings raise the hypothesis that CP-870,893acting as a potent and selective agonist of CD40...
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báo cáo hóa học: " Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures" pdf

... receptors in the induction of PGE2 production by activated microglial cells. COX-2 is the inducible isoform of the enzyme responsible for the first committed step in PGE2 synthesis, one of themajor ... levels of induction, have been associated with both protective and harmful effects on neurons and glial cells [27]. In micro-glial cells, COX-2 is the major isoform, rapidly induced by LPS stimulation ... µg/ml of streptomy-cin, and 2 mM L-glutamine. The cells were plated in 12-well plates for 24 h before performing RNA extraction.Cytokines nitric oxide and PGE2 determinationAt the end of the...
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báo cáo hóa học: " Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration" docx

... NADPH oxidase in the presence of glial iNOS is synergistic in killing co-cultured neuronsFigure 2 Activation of NADPH oxidase in the presence of glial iNOS is synergistic in killing co-cultured ... by microglia, is seen in post-mortem brain tissue, in transgenic models of thedisease, and in culture [61]. A peptide, consisting of resi-dues 106–126 (PrP106-126) of the human prion protein,replicates ... mainly by extracel-lular and intracellular superoxide dismutase to givehydrogen peroxide (H2O2).iNOS is not normally expressed in the brain, but is induced in astrocytes and microglia by...
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báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt

... Yoshida A, Ishibashi T: Induction of IL-8, MCP-1, and bFGF by TNF-alpha in retinal glial cells: implications for retinal neovascularization during post-ischemic inflammation. Graefes Arch Clin Exp ... apoptosis in this condi-tion [9]. However, TNF may also be directly involved in the formation of retinal NV in the later stages of theOIR model. In this study, we investigated the temporal and ... indicatingthat microglial cell density may not be the critical factor for OIR. It may provide a base for the functional investi-gation of the influence of microglial cells on retinal tuftformation.Authors’...
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Báo cáo hóa học: " A biofeedback cycling training to improve locomotion: a case series study based on gait pattern classification of 153 chronic stroke patients" pdf

... speed and symmetry.The training consisted of a 2-week treatment of 6 sessions. A visual biofeedback helped the subjects in maintaininga symmetrical contribution of the two legs during pedaling. ... were obtained by subtracting the mean tor-que computed during passive cycling from the torqueprofile calculated during each revolution of voluntarypedaling. In this way, the inertial and gravitational ... comparison between the performanceobtained by the three patients during the first (upperpanels) and the last (lower panels) day of treatment in termsofworkproducedbythetwolegsduringthe8minutes of...
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báo cáo hóa học: " Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson''''s disease" potx

... effects of con-ventional NSAIDs, which inhibit both isoforms of COX(constitutive and inducible). COX-2 is induced by pro-inflammatory stimuli and cytokines [25]. Inhibition of the inducible form ... DA quinones can deplete the cells of antioxidants,inactivate enzymes and increase α-synuclein protofibrils[56,63]. Induction of COX-2 results in an inflammatorycascade accompanied by formation ... neurodegenerativedisorders, including Parkinson's disease (PD) [2-4]. Glial activation is part of a defense mechanism to removedebris and pathogens and promote tissue repair. How-ever, inflammatory activation...
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Báo cáo hóa học: " Some nonlinear delay integral inequalities on time scales arising in the theory of dynamics equations" ppt

... Qufu,Shandong, 273165, ChinaFull list of author information is available at the end of the articleAbstract In this paper, some new nonlinear delay integral inequalities on time scales areestablished, ... attention by manyauthors, and a lot of integral inequalities on time scales have been established (see[5-10] and the references therein), which are designed to unify continuous and discreteanalysis, ... attention so far in the literature.Recent results in this direction include the works of Li [11] and Ma [12].Our aim in this paper is to establish some new nonlinear delay i ntegral inequalitieson...
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