... [17].Tremelimumab is a fully human IgG2 monoclonal antibody with high binding affinity for human CTLA-4 [18]. This anti-body is in late stages of clinical development in patients with metastatic melanoma ... AccessResearchCTLA4 blockade increases Th17 cells in patients with metastatic melanomaErika von Euw1, Thinle Chodon2, Narsis Attar2, Jason Jalil1, Richard C Koya1, Begonya Comin-Anduix1 and Antoni ... cytokine-producing cells by intracellular cytokine staining (ICS).Results: There were no significant changes in 13 assayed cytokines, including IL-17, when analyzingplasma samples obtained from patients...