... fromnecrotic cells but not from most apoptotic cells. The rea-son for this is unknown, but has been hypothesized to bea result of either redox changes or under-acetylation of histones in apoptotic cells ... breast cancer cells. S100A6 binds to the tetramerization domain of p53 [104]. S100A6bound significantly to the C2 domain of RAGE, asopposed to the V and/or C1 domains to which most otherligands ... regulating autophagy[63]. Although HMGA1 has a role in the export of HIPK2(Homeodomain-interacting protein kinase 2, a proapop-totic activator of p53) from the nucleus to the cytoplasm[64], the HMG...