báo cáo hóa học:" Isolated cystic tuberculosis of scapula; case report and review of literature" docx
Báo cáo hóa học: "DNA polymeraseh protein expression predicts treatment response and survival of metastatic gastric adenocarcinoma patients treated with oxaliplatin-based chemotherapy" pot
... design of the study. RZL and HZZ reviewed the IHCslices. ZQW and YHL participated in the statistical analysis. RHX conceived of the study, and participated in its design and coordination and helped ... chemo therapy. With this standard,only 23 patients had positiv e expression, with 7 out of 62 clinical benefit cases (CR+PR+SD) from chemother-apy and 16 out of 18 PD cases. The expression ratebetween ... protein expression and clinical features and outcome of thesepatients was analyzed.Results: A positive linear relationship between pol h protein expression and 48 h IC50 values of oxaliplatin in...
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báo cáo hóa học:" Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin" docx
... level of ABCC2 mRNAexpression for about 72%, and named as CNE2/shABCC2-1 and -2, respectively (Fig. 1B).To further confirm the specificity of siRNA-mediatedsilencing of ABCC2, the detection of ... calibration curve was y = 1.59x +17.917(y stands for peak height of cisplatin and x standsfor concentration of cisplatin). Based on this equation,the concentration of cisplatin for each sample was deter-mined. ... mRNA and protein expressions of ABCC2 in NPC cellsFigure 1Special siRNA targeting ABCC2 silences the mRNA and protein expressions of ABCC2 in NPC cells. (A) Expression of ABCC2 mRNA in NP69 and...
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báo cáo hóa học:" Tremorgenesis: a new conceptual scheme using reciprocally innervated circuit of neurons" pptx
... One of the reasons is our lack of under-standing in the pathogenesis and natural history of severaltremor disorders.Current theories suggest that tremor is driven by complexcombinations of ... models of tremor [7]. This isthe case for instance with the model of acute administra-tion of harmaline in rodents [8], widely used to mimicessential tremor, or for the animal models of Parkinson'sdisease ... valid model of rest tremor. Trying to isolatemechanisms of tremor from four-footed animals and toextrapolate them to human beings is not straight-forward.Developments of convenient and reproducible...
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báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt
... avariety of human and rodent tumors [5,6,10,11] and thatsynthetic ligands to this receptor could play an importantrole in cancer diagnosis and therapy [12]. We have previ-ously reported that ... pancreas cancer and weakly expressed in nor-mal pancreas [13]. In this same study, we carefully charac-terized the receptor-ligand binding interaction and reported the Kd and Bmax values of sigma-2 ... for pancreas cancer and are an excitingclass of compounds for potential treatment of thesemalignancies.MethodsSigma receptor ligandsSigma-2 specific ligands SV119, SV95, and fluorescent -labeled...
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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc
... assay.HPLC analysis of the synthesis and release of DA by RPE cellsFigure 5HPLC analysis of the synthesis and release of DA by RPE cells.(A) HPLC analysis of standard of DA, 3,4-dihy-droxyphenylacetic ... designed by MM and WL and were per-formed by MM, XL, and XF. Human RPE cells were sepa-rated and cultured by QG. DY, LL and SC gave advises onthe work and helped in the interpretation of the data. ... protectiveeffect of RPE-CM is mediated by the secretion of GDNF and BDNF. We found the RPE-CM contained high levels of GDNF (0.019 pg/ml) and BDNF (0.49 pg/ml) (Table1). Furthermore, adding antibodies of...
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Báo cáo hóa học: " Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits" pot
... extraction and CTLassays.All the animals were housed and handled in accordancewith the European guidelines no. 86/609/CEE and 116/92for the protection of laboratory experimental animals and laboratory ... HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits Journal of Translational Medi-cine 2010, 8:40Radaelli et al. Journal of Translational ... used as negative and irrelevant con-trols. Cytolytic E6- and E7-specific T-cell activity were induced in most of the rabbits (Protocols 1 and 2; [E:T] ratio 30:1). Rabbit # 81 of Protocol 3/E7...
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Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
... molecular and biological fea-tures of the modified cells and the method of theirproposed administration. This Commentary presents anexample of such a discussion from the current state of theart ... (engraftment AND 2nd generation) is too muchrisk. A 0 → Strategy 4 test presumes much about thequality of our knowledge of the potential normal tissuetargets and their susceptibility, and, of all ... application. For the same target and CAR recognition domain, a diversity of signalingdomains, co-expressed cytokines and anti-apoptoticgenes may impact the survival and activity of the designerT cells,...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... kground of the host, microflora and targettissue. As such, Tregdepletion, or alterations of the foxp3gene, as seen in Scurfy mice or IPEX patients, results in aloss of Tregcells, and catastrophic ... anefficient and timely targeting of activated Treg versusTeff cells during distinct p hases of T1 D progression.Several studies report the use of several strategies tomodulate IL-2 signals and ultimately ... the world. As such, tw o sets of SNPs have been identified in the 5’ and 3’ vicinity of th epromoter of IL-2RA [29-31]. The molecular and func-tional consequences of these SNPs remain to be charac-terized,...
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Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... very well be at the heart of boththe mechanism and advantage of heterologous prime-boost regimens. Therefore, the remainder of this review will focus on this key feature and its underlyingmechanism, ... properties of non-replicating vectors and biological response modifiers bydirect intra-nodal administration of plasmid and pepti de[19,41]. We showed that the sequence and the route of administration ... mechanismsC. Major features of synergistic priming and boosting regimensFigure 7 Co-regulation of PD-1 acquisition and functional avidity of T cells during immune priming. A and B show schematically...
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báo cáo hóa học: " Cardiac rehabilitation in Austria: long term health-related quality of life outcomes" pptx
... the reduction of symptoms and theimprovement of physical functioning and general wellbe-ing [1,2]. These outcomes are typically considered to bepatient-reported outcomes (PRO) and have top-tier ... (QALYs) [24]. The EQ-5D consists of a 5-dimensional descriptive system and a visual analoguescale allowing assessment of relevant segments of HRQL:Health and Quality of Life Outcomes 2009, 7:99 ... Assesment of quality -of- life out-comes. The New England journal of medicine 1996, 334(13):835-840.30. Rozanski A, Blumenthal JA, Kaplan J: Impact of psychological fac-tors on the pathogenesis of...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt nam