... expressedboth by melanocytes and melanoma cells. Among the melanoma-associated Ags identified so far, Melan -A hasreceived particular attention because of its immune dom-inance in HLA -A2 + patients. A large ... clearer.Conclusion The finding of a conserved amino acid motif in the CDR3,together with the selective use of certain TRBJ and TRBVsegments, indicates an important role of the TRB chain in fine-tuning TR affinity ... affinity of Melan -A- specific T cells of melanoma patients and argues against the hypothesis thathigh affinity TRs against self-Ags, like Melan -A, areremoved during selection in the thymus or, alternatively,by...