... Thus, we investigated the biologicaleffectsofVEGFinGCTsusingGCT-CMandrOPCs.Consistent with the immunohistochemistry results,GCT-CM contained VEGF and treating rOPCs withGCT-CM resulted in the ... lineage cells, including OPCs and OCs [20].Therefore, it is possible that the infiltrating MNCs and monocyte-like cells in GCTs mature into OCs and OPCs, respecti vely. In contrast, the stromal cells ... manyother cytokines, including TGF-b1[5], MCP-1[6] and M-CSF, in GCTs influence the chemotaxis and growth of rOPCs. Meanwhile, a recent study showed that GCTsenhanced osteoclastogenesis via paracrine...