... studies were designed by ELC, JR, and RHV and wereperformed by ELC. ELC and RHV wrote the paper together with RM and JR. RM provided all statistical analyses. Allauthors read and approved the final ... is agonistic and activates naïve and memory Bcells with properties consistent with licensed APC. B cellactivation with CP-870,893 can be further increased with TLR9 co-stimulation and can be ... both memory and naïve B cellscan be activated by the drug CP-870,893, and this CP-870,893 effect can be increased by the addition of CpGODN 2006. Naïve B cells, as defined by lack of CD27expression,...