... distribution (Fig. 1) , in which the SPP1 representatives are at the basal branch of CGBPand DIO. The GCBP proteins contain a PHD domain, fol-lowed by a DNA-binding domain (the zf-CXXC) and the newly ... Dawid IB (19 90) The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein withzinc-binding domains. Proc Natl Acad Sci USA 87, 211 2– 211 6. 14 Tripoulas ... of chromatin [9]. Little isknown, however, of the functional role of the remain-ing subclass members. In this study, the yeast protein SPP1 (alias cps40), amember of the COMPASS complex [10 ],...