... (NMO), a severe inflammatory demyelinating disorder, has gained increasing interest since the discovery of serum NMO-IgG autoantibodies targeting the aquaporin-4 (AQP4) water channel protein [1, ... Neuropediatrics 2007, 38(5):257-260. 41. Kinoshita M, Nakatsuji Y, Moriya M, Okuno T, Kumanogoh A, Nakano M, Takahashi T, Fujihara K, Tanaka K, Sakoda S: Astrocytic necrosis is induced by anti-aquaporin-4 ... quantitation of complement-mediated injury to aquaporin-4-expressing cells. Arch Neurol 2009, 66(9):1164-1167. 43. Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe...