báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt
báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt
... 8:120http://www.jneuroinflammation.com/content/8/1/120Page 2 of 8RESEARC H Open Access Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse ... 1B and 2E). Microglial cell density was always higher in the superficial than in the deep retinal layer (Figure 3). The microglial cell density in the peripheral zone, where the retinal vascu-lar ... involved in the formation of retinal NV in the later stages of the OIR model. In this study, we investigated the temporaland spatial distribution of microglial cells during the dif-ferent stages of...
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báo cáo hóa học: "Impact of gastroesophageal reflux disease on patients'''' daily lives: a European observational study in the primary care setting" doc
... management in the primary care set-ting, tailoring treatment on an individual basis in order tolessen the impact of the disease. This may be aided with the use of well suited, validated PRO instruments.Mean ... onesuch instrument, providing more accurate and sensitivequantification of the symptoms and the impact of these in patients with GERD, and thereby facilitating better man-agement of disease.Conclusion The ... disease.Conclusion The findings of this European observational study showthat a proportion of patients with GERD are inadequatelytreated, having clinically relevant impact on their dailylives. These data indicate...
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Báo cáo hóa học: " Reversal of TMS-induced motor twitch by training is associated with a reduction in excitability of the antagonist muscle" ppt
... and the possibility of extending the training over time, is relevant in deter-mining the optimal parameters to maximize the magni-tude and duration of the observed effects. The effect of ballistic ... encoded in the corticospinal system with move-ment repetition of the wrist, consistent with an earlyphase of learning, and involve release of activation toantagonist muscles. These findings may ... ramppinch task, an increase in force and acceleration, asso-ciated with an increase in MEP amplitude, was observed in the muscle involved in the training, but not in a mus-cle unrelated to the...
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báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc
... pharmacodynamic effect on B cells isparticularly interesting in light of increasing evidence thatB cells can regulate tumor cellular immunity. Recent find-ings in murine models demonstrate that ... peripheralblood B cells in the presence of increasing concentrations of CP-870,893 or purified human IgG2 (from zero to 10ug/ml), washing the cells, then labelling with either AbdSerotec anti-CD40 ... previouslyshown in murine models to activate APC and enhance tumor immunity; in humans, CD40-activated DC and Bcells induce tumor-specific T cells in vitro. Although clinical translation of these findings...
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báo cáo hóa học: " Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures" pdf
... receptor activation using the specific agonist nicotine. Microglial cells were pre-treatedfor 30 min with increasing concentrations of nicotine andthen incubated for 4 or 24 h in the absence or the ... of nicotine and α7 subunit activation on interleukin-10 and prostaglandin E2 synthesis by rat microglial cellsWe then analyzed the effects of nicotine on the produc-tion of interleukin-10 ... receptors in the induction of PGE2 production by activated microglial cells.COX-2 is the inducible isoform of the enzyme responsiblefor the first committed step in PGE2 synthesis, one of the major...
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báo cáo hóa học: " Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration" docx
... protein andpeptide were synergistic in killing neurons in the presence of glial iNOS, in a peroxynitrite and microglia- dependentmechanism. The addition of the cellular isoform of prionprotein ... potentiateLPS/IFN-γ induced neuronal death, we added extra iso-lated microglia to the neuronal-glial culture, increasing the microglial population from 2% to 15% of cells in the co-culture. In such microglia- enriched ... proliferation of microglia in neu-ronal-glial cultures, even in the presence of LPS/IFN-γ(which itself inhibits microglial proliferation). In order totest whether an increase in microglia would...
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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc
... [14,15], the mechanisms of EGF-like factor andTACE/ADAM17 expression in cumulus cells cultured with FSH and/or LH have remained unclear during in vitro mat-uration of porcine COCs. The binding of ... status of ERK1/2 was detected. The addi-tion of H89 or SB20580 to the medium significantlydecreased the intensity of bands as compared with those in cumulus cells of COCs cultured without any inhibitor,and ... the lower level of these gene expressions resulting from the addition of U0126 was not overcome by the addition of EGF, the addition of EGF to H89- or SB203580-contain-ning medium overcame the...
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Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
... molecules integrins in gastricepithelial cells. In the present stu dy, the role of PAR-2 on H. pylori-induced cell death was investigated bydetermining cell viability, DNA fragmentation, and the activation ... of PAR-2 expression suppresses H. pylori-induced activation of MAPK in gastric epithelial cellsTo determine the role of PAR-2 on the activation of MAPK, the activation of three major MAPK involved ... 8:85http://www.translational-medicine.com/content/8/1/85Page 4 of 7epithelial cells. This result is consistent with the pre-vious studies showing that the activation of PAR-2 isrelated to the activation of MAPK in mouse...
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Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc
... DC-to-T cell ratio(1:27). The percentage of proliferating T cells residing within each cell generation (G) was calculated with the proliferation wizard of the ModFit™ software. Median values and interquartile ... stimulatingfactor treatment of Crohn’s disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propriaplasmacytoid dendritic cells. Clin Exp ... and filgrastim differ in their ability to skewmonocyte function, with the former supporting the in vitro development of activating DC and the latter favor-ing the emergence of tolerogenic DC preparations...
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Báo cáo hóa học: " Effects of muscle fatigue on gait characteristics under single and dual-task conditions in young and older adults" ppt
... of the study, assisted in the recruitment of subjects, did the testing, participated in data analysis anddrafting of the manuscript. SB participated in the design of the study,assisted in the ... andwrote the manuscript. IW participated in the design of the study, recruitedsubjects, did the testing, participated in data analysis and drafting of the manuscript. AW participated in the design of ... of Helsinki.TestingUpon entering the gait laboratory, participants receivedinstructions regarding the test procedure with a visualdemonstration of the walking and the strength tests.Thereafter,...
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