... immunohistochemistry for Her2 (a, membranous staining and Her3 (b, membranous and cytoplasmic staining, and c, predominant cytoplasmic staining) 400 × magnification.Takikita et al. Journal of Translational ... 9:126http://www.translational-medicine.com/content/9/1/126Page 7 of 10RESEARCH Open Access Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinomaMikiko ... differentiation, migration,proliferation, and survival. Her2 has an extracellular domain, but appears to lackligand-binding activity, while Her3 has a non-functionalkinase domain and has no catalytic...