báo cáo hóa học: " Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9" docx

... 2005, and October until November 2005.MeasuresThe Inventory for Assessing the Quality of Life (ILC)This measure was developed in Germany by Mattejat and colleagues as a short and practical assessment ... 14:1573-1584.7. Chen X, Sekine M, Hamanishi S, Wang H, Gaina A, Yamagami T, Kag-amomori S: Lifestyle and health-related quality of life in Japa-nese school children: a cross-sectional study. Prev Med 2005,40(6):668-678.8. ... sample was representativefor the general population of the county in regard tomale:female and urban:rural ratios as well as age range.Because the QoL measures in the sample were only mini-mally...

... 1 of 15(page number not for citation purposes)Journal of NeuroinflammationOpen AccessResearch Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and ... effects of NE on IL-1β were observed at concen-trations lower than that needed for maximal inhibition of NOS2 expression, and resulted in greater extent of inhibi-tion (over 80% inhibition of IL-1β ... An under-standing of the contrasting effects of PKA and AC inhibi-tors on nitrite production and NOS2 expression maytherefore help to explain reported divergent effects of cAMP on microglial...

... AccessResearch Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemiaManu Jatana1, Shailendra Giri1, Mubeen A Ansari1, Chinnasamy ... Gilg AG, Sekhon C, Singh I, SinghAK: Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci ... injury in rats via down-regulation of theinflammatory mediators NF-κB and iNOS. Thus, inhibit-ing the 5-LOX /NF-κB pathway holds therapeutic potentialto attenuate inflammation-mediated brain...

... purposes)Journal of NeuroinflammationOpen AccessResearch Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9Timothy J Cunningham*, Jaquie Maciejewski and Lihua ... elevation of sPLA2s are associ-ated with most forms of inflammation [1-5]. The secreted isoforms are part of a growing family of PLA2 enzymeswhose activity leads to the production of several ... stress, and therefore are con-sistent with the peptide& apos;s performance in vivo.MethodsSources and preparation of sPLA2Purified secreted phospholipase A2 group I from thevenom of the Mozambique...

... NeuroinflammationOpen AccessResearch Inhibition < /b> of < /b> the < /b> alternative < /b> complement < /b> activation < /b> pathway < /b> in < /b> traumatic < /b> brain < /b> injury < /b> by < /b> a < /b> monoclonal < /b> anti-factor < /b> B antibody: a < /b> randomized placebo-controlled study in < /b> miceIris ... expression.Conclusion: Inhibition < /b> of < /b> the < /b> alternative < /b> complement < /b> pathway < /b> by < /b> posttraumatic administration of< /b> a < /b> neutralizing anti-factor < /b> B antibody appears to represent a < /b> new promising avenue forpharmacological attenuation ... extrapolate thesefindings to a < /b> pharmacological model by < /b> targeted inhibi-tion of < /b> the < /b> alternative < /b> pathway < /b> [35]. We therefore used a< /b> newly available, highly specific and potent inhibitor of< /b> the < /b> alternative...