báo cáo hóa học: " 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia" pptx
báo cáo hóa học: " 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia" pptx
... LPS /Aβ- induced inflammatory processes by blocking the expression of proinflammatory cytokine, iNOS, COX-2 and MnSOD genes, and by inhibition of ROS generation and depletion of glutathione in astroglial ... AICARattenuation of LPS- or cytokine /Aβ- induced expression of inflammatory mediators (e.g. iNOS, COX-2 and cytokines) by inhibiting the activation of transcriptionfactors (NFκB and C/EBP) required for induction ... purposes)AICAR inhibits LPS- and Aβ- (25–35) induced expression of iNOS, COX-2, and MnSOD in astrocyte-enriched glial cellsFigure 4AICAR inhibits LPS- and Aβ- (25–35) induced expression of iNOS, COX-2, and...
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báo cáo hóa học:"Phylogenetic evidence for the distinction of Saaremaa and Dobrava hantaviruses" pdf
... participated in the analysis of the results and drafted the manuscript. AV participated in the analysis of the results and helped to draft the manu-script. AP designed the study, participated in the ... sequences, and phylogenetic trees were created on partial sequences, thatwere possibly of recombinant origin. Although we havefound some indications on a recombinant origin of the strain Lolland (in ... amosaic-like pattern of the N protein sequence of Lollandstrain. Moreover, the presence of this sequence did not"break" the molecular clock (see below). The Lollandsequence was, therefore,...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... areclosely interlinked in the function of the enzyme complex.Studies in yeast have shown that both oxygen and heme actas physiological modulators and regulate the expression of the enzyme complex ... (CytOX) is the terminal oxidase of the mitochondrial electron transport chain [1–5], whichcatalyzes the reduction of the dioxygen (O2) to water and harnesses the free energy of the reaction ... [4,5]. The remaining 10 subunits of the mammalian enzyme, namely, IV, Vb, VIa, VIb, VIc, VIIa,VIIb and VIII are encoded by the nuclear genome,synthesized in the cytosol and imported into mitochondria[1–3]....
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báo cáo hóa học: " Exploring disability from the perspective of adults living with HIV/AIDS: Development of a conceptual framework" docx
... HIV and its resulting disablement. Strategies included seekinginteractions with others, maintaining a sense of controlover life and the illness, 'blocking HIV out of the mind', and ... serious illness; and suffering a loss of oth-ers (Table 2).DiscussionFindings from this thesis include a new framework forunderstanding disability in the context of HIV. Resultsindicate that ... grounded theory, based on the principles of Strauss and Corbin [13]. We used a systematic set of procedures which included: breaking transcript datadown line-by-line into concepts termed meaning...
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Báo cáo hóa học: " Beyond satisfaction: Using the Dynamics of Care assessment to better understand patients'''' experiences in care" pptx
... findings in the description of each analysis.Stage of help-seeking and factors that influenced help-seeking decisions The first section of the Dynamics of Care interviewassesses whether and ... series of analyses of the psychometric and response properties of each section in the Dynamics of Care, including stage of help-seeking, barriers and delaysencountered while seeking help, and perceived ... from the baseline and three-month interviews. The informed consent process occurred at the time of the base-line interview. Each interview took 30–45 minutes tocomplete and was conducted either...
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báo cáo hóa học: " Approximate entropy detects the effect of a secondary cognitive task on postural control in healthy young adults: a methodological report" docx
... purposes) the subject's predetermined (seated) digit span. Uponreciting the final digit in the string, the examiner initiatedCOP recording, and the subject repeated the digit stringaloud ... even in a relativelysmall sample. More research is needed to confirm the cur-rent findings, expand our understanding of what consti-tutes meaningful clinical change in ApEn values, and determine ... influ-ence the amplitude of COP variability even in the absence of a changing attentional demand [9,11]. Whether the mechanical influence of vocalization extends to the tem-poral structure of COP...
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báo cáo hóa học: " Participatory design in the development of the wheelchair convoy system" potx
... factors in this prototype of the WCS were the limited field of view of the camera, lack of degrees of free-dom in the camera mounting, and the low quality of the image. The field of view and lack of ... purposes)mined the distance between the wheelchairs based on the number of rotations of the spool holding the string, and determined the angle between the leading wheelchair and trailing wheelchair ... attached, with the JWI (and third prototype of the WCS) in the middle and the pow-ered wheelchair (and fourth prototype of the WCS) trail-ing. A picture of the experimental set-up is shown in Figure...
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báo cáo hóa học: " Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42" pdf
... of ginkgolides. Variations in the ginkgolide content of differ-ent extracts may be a factor in the variability of resultsobtained in clinical studies. The ginkgolides inhibit the activity of ... murine scrapie[21] and AD [22]. The presence of ginkgolides greatlyreduced the activation of apoptotic pathways in thesecells. The presence of ginkgolides also reduced microglialkilling of ... protectiveeffect of the ginkgolide B could be overcome by increasing the concentration of sPrP106 or amyloid-β1-42. In AD and prion diseases the loss of neurons in vivo occurs thoughapoptosis [3,20], and...
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báo cáo hóa học: " Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation" potx
... activation, resulting in elevated expression of specific cytokines, upregulation of eicosa-noid biosynthetic pathways, and increased oxidant pro-duction. The act of plating and culturing the cells ... progression in the ALS mouse [14]. These findings suggest a robust,multi-faceted neuroinflammatory response, antagonism of which may slow the progression of ALS. In order to better understand the contributions ... ALS-linked glial activation. The time-course of cytokine up-reg-ulation closely mirrors the time-course of protein oxida-tive damage, and begins approximately two weeks prior to the point of...
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báo cáo hóa học:" New views on the hypothesis of respiratory cancer risk from soluble nickel exposure; and reconsideration of this risk''''s historical sources in nickel refineries" potx
... aGroup I carcinogen [51], in the leaching of nickel matte and electrowinning processing at Harjavalta [52]. The wearing of protective breathing apparatus in the refinery'selectrowinning halls ... shippedto KNR for final processing. In both sinter plants, sinteringpreceded the smelting step. In contrast, sintering followed the smelting step in both the Copper Cliff (CC) sinterplant and PCNR's ... Shannon HS: A study of mortality in workers engaged in the mining, smelting, and refining of nickel. II: Mortality from cancer of the respiratory tract and kidney. Toxicology and Industrial Health...
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