... expressed iNOS produces high, sustained levels of NO which can, in certain conditions, kill nearby neurons, by mechanisms including inhibition of mitochondrialrespiration and the release of glutamate ... by inhibitors of iNOS, NADPH oxidase and a peroxynitritescavenger, but not by the NMDA receptor blocker. Activation of NADPH oxidase in the presence of iNOS expression leads to 3-nitrotyrosine ... cultures, and this proliferation was blocked by a NADPH oxidase inhibitor. Both prion protein and peptide were synergistic in killing neurons in the presence of glial iNOS, in a peroxynitrite and microglia-dependentmechanism....