... Garsky, V.M. & Kuo, L.C. (1996) Mutationalanatomy of an HIV-1 protease variant conferring cross-resistanceto protease inhibitors in clinical trials. Compensatory modulations of binding and ... to the appearance of mutations in the PR gene. Many of these mutations are located in thesubstrate binding site of the PR, and these mutationshave considerable impact on PR activity and specificity.Other ... Georgia State University, Atlanta, GA, USA;3Laboratory of Chemical Physics, National Institute of Diabetes,Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA;4NCI-Frederick,...