... diver-sity of auto-immune comorbidities that are common in the autistic population. It is possible that pioglitazone effects are, in part or in full, an indirect consequence of reducing symptoms of the ... due to theirinsulin sensitizing effects, and several are now in clinicaluse. In addition to insulin sensitizing effects, TZDs alsoexert anti-inflammatory effects on a variety of cell types,and ... TZDs, in the pediatric population requiresadditional testing.Conclusion In view of its established safety profile, the current resultsprovide the rationale for further testing of pioglitazone in autism...