Báo cáo sinh học: " Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases" pot
Báo cáo sinh học: " Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases" pot
... CentralPage 1 of 20(page number not for citation purposes)Virology JournalOpen AccessHypothesis Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications ... variable RNA pol fidelity and processivity, restriction of antigenic diversity and immune recognition under influence of Replicative homeostasisFigure 7Conceptual progression of intracellular viral ... genera-tion of RNA quasispecies by RNA pol, and translation of these immensely variable RNAs into protein quasispecies, suggests an immediate solution to the problem of viral autoimmunity and, by...
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báo cáo hóa học:" Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases" doc
... JournalOpen AccessHypothesis Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other ... diversity and immune recognition under influence of Replicative homeostasisFigure 7Conceptual progression of intracellular viral replication events, including variable RNA pol fidelity and processivity, ... processivity, restriction of antigenic diversity and immune recognition under influence of Replicative homeostasis. Panels (A->E) changing frequency distri-bution of viral RNA and protein quasispecies, ...
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Báo cáo sinh học: " Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study" doc
... important limitations for mixed virus populations and for the detection of emerging orresidual virus variants. The interpretation of a GRTresults becomes particularly challenging for therapy-experienced ... the viral popula-tion and is able to dissect mixed virus populations. Theshort assay duration (6 days) obviates de novo evolution of resistance in vitro. Details and a comparison withnon -replicative ... prediction of drug response. On the other hand, comparing different algorithms, some very sig-nificant differences and op posite predicti ons continue tobe observed for the interpretation of the...
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báo cáo hóa học:" Replicative Homeostasis: A fundamental mechanism mediating selective viral replication and escape mutation" ppt
... number not for citation purposes)a. Constraints on viral mutationFigure 3a. Constraints on viral mutation. Inadequate polymerase fidelity will cause loss of sequence information and quasispcies ... rate of viral replication and degree of viral muta-tion. Intracellular envelope concentrations are a directfunction of effective viral replication, while competitionbetween wild-type and variant ... bydefective virus [34]. Thus, there exists solid evidence for each necessary component of replicative homeostasis for HCV, HBV and HIV, and other viruses. Replicative homeostasis: proposed mechanismReplicative...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
... clearcorrelation between results of immune monitoring and clinical benefit in terms of tumor responses. This lack of correlation of immune parameters and response mayrelate to the likely low sensitivity of ... rol(objective responses by RECIST plus SD beyond 8weeks)rateof20%,anullresponserateof5%,atypeone error of 0. 10, and a type two error of 0.10. As such,continuation to the second stage required one patientoutofthefirst12recruitedtodemonstratepositivetumor ... significantregression of cutaneous lesions (concomitant changes inpigmentation and nodularity) with continued dosing.Resection of two nodules at weeks 24 and 36 showed noevidence of viable melanoma;...
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báo cáo sinh học:" The training and expectations of medical students in Mozambique" doc
... and for another third, over US$ 1429. These expectations are putinto context when one notes that the salary of a newlyExpectations of future monthly incomeFigure 4Expectations of future monthly ... aim of identifying their social and geo-graphical origins and their expectations and difficultiesregarding their education and professional future.MethodsA piloted, standardized questionnaire, ... (86% of thosebeing women).ResultsThis section reports on the students' backgrounds, on thedecision to study medicine, on their academic perform-ance and on difficulties and expectations.Distribution...
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báo cáo sinh học:" Empowering the people: Development of an HIV peer education model for low literacy rural communities in India" pdf
... dispersion of the population of this district (1.2 million people; 3690 square kilome-tres) impedes distribution of correct information [4].Many villages lack public transportation and can only ... loans for micro-enterprise development).Monitoring and evaluationThe evaluation of PEPP involved the collection and anal-ysis of both quantitative and qualitative data. Triangula-tion of data ... promoters of public health became a source of pride and additional social recognition, which may fur-ther contribute to the sustainability of the peer dialogue and communication on HIV- and AIDS-related...
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báo cáo sinh học:" Appropriate training and retention of community doctors in rural areas: a case study from Mali" pdf
... of training needs, contributed to the design, implementation and evaluation of the programme and revised the manu-script. SC and MS contributed to the design, implementa-tion and evaluation of the programme, ... environment and work-ing conditions [2,16]. Individual professionals have dif-ferent backgrounds and expectations, but also vary interms of self-confidence, which impinge on job satisfac-tion: ... continuing training, mentoring ) affecting job satisfaction.Conclusion: Training increasing self confidence and self esteem of rural practitioners maycontribute to retention of skilled professionals...
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báo cáo sinh học:" What impact do Global Health Initiatives have on human resources for antiretroviral treatment roll-out? A qualitative policy analysis of implementation processes in Zambia" pptx
... acknowledge the contribution of Virginia Bond, Gill Walt and Lucy Gilson. Research collaboration was supported by the Evidence for Action research consortium at the London School of Hygiene and Tropical ... mentoring,coordination and recruitment of staff.The research conducted is qualitative, so relies on, and islimited to, the perceptions of persons interviewed atnational level, in one province and two ... this information [18].Despite the limitations in detailed information, broadinformation on funding was obtained. Interviews withkey stakeholders confirmed that the preponderance of funding for...
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báo cáo sinh học:" Migration as a form of workforce attrition: a nine-country study of pharmacists" pptx
... propensity for migration.Conclusion: Given the influence of the country context and environment on migration intentions,research and policy should frame the issue of migration in the context of the ... migration as one form of attrition and a symptom of other root causes.Remuneration is not an independent stand-alone factor influencing migration intentions and cannotbe decoupled from professional ... migration intentionFigure 1Attitudes towards home country professional and sociopolitical environment and opportunities abroad by migration intention.Migration intentionsLong-termTemporaryNoneMean...
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