... CyP's capacity to impair innate resistance to
HSV-1 [56,57]. Further study is needed to test this
hypothesis.
Role of Stat 1 in innate resistance to HSV-1
The biological functions of IFN-α/β and ... Central
Page 1 of 15
(page number not for citation purposes)
Virology Journal
Open Access
Research
Re-evaluating the role of natural killer cells in...
... designed on the basis of side-chain packing criteria
from a modelled structure of the enzyme resulted in restor-
ation of the energy of activation to the levels of the native
enzyme and in an increased ... doi:10.1046/j.1432-1033.2002.02895.x
strain TAB5. We particularly attempted to investigate the
functional importance of the Gly pair, located in the vi...
... number of test documents and find that the fea-
ture vectors corresponding to some of these docu-
ments (particularly the short ones) have all zeroes
in them. In other words, none of the bigrams ... im-
portantly, an analysis of these results show that the
various types of features interact in an interesting
manner, allowing us to draw conclusions that pro-
vide ne...
... with these
mutations binding of NADPH was still too weak to
allow determination of a K
d
value in the absence of
the other substrate. In the presence of oxoglutarate,
however, coenzyme binding ... NADH. Lysine is closer in size to the
glutamate it replaces than arginine, and it is possible
that the latter is too large to allow optimal orientation
of the coenz...
... with the histidine residue of the
H-loop, and positions the ‘linchpin’ histidine in the
correct orientation such that all atoms are then in
position to favor abstraction of a proton from the
attacking ... proteins. To answer this
question, we took advantage of the trypsin-sensitive
region situated in the linker domain of Abcb1a. Fol-
lowing trapping in the...
... FEBS
Dissecting the role of the N-terminal metal-binding
domains in activating the yeast copper ATPase in vivo
Isabelle Morin
1,2,3,
*, Simon Gudin
1,2,3
, Elisabeth Mintz
1,2,3
and Martine Cuillel
1,2,3
1 ... the N-terminus of Ccc2
is not only involved in receiving copper from Atx1,
but also plays a crucial role in the overall function of
the ATPase by deliverin...
... unsure of the mechanism
of DNA-induced stabilization of the protein, and whe-
ther it is related to the normal RNA-binding function
of coat protein, as RNA binding had no effect.
The increased ... understood, and we have investigated these
questions in this work. We sought to determine the
role of protein–RNA and protein–protein interactions
in virus stability,...
... mandatory for inference. In another 28%,
references could optionally support the inference
of the hypothesis. In the remaining 28%, refer-
ences did not contribute towards inference. The
total ... enough;
(3) the limitation to nominal coreference; and (4)
overly simple integration of reference information
into the inference engines.
The goal of this paper is to ass...
... it to the flavin ring through
the S80 side-chain [22]. Such observation also suggested that
in E301A FNR the side-chain of E139 might in uence the
properties of the flavin, assuming some of the ... conformational chan-
ges in the side-chain of another glutamic acid residue, E139,
that in the mutant points towards the FAD cofactor in the
active centre cavit...
... of
medulloblastoma cells in a wound scratch assay. DAOY
cells were grown into near confluence when a wound was
created in the center of the monolayer, and the ability of
neighboring cells to migrate into the ... capability of medulloblastoma
cells.
In summary, we found a novel role of MHC class I con-
tributing towards a more malignant phenotype of medul-...