Báo cáo hóa học: " Do quality of life, participation and environment of older adults differ according to level of activity?" pdf
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf
... investigation of HGFA activation in vivo, as well as regulation of HGFA activity by endogenous protease inhibitors,including hepatocyte growth factor activator inhibitor-1(HAI-1) and protein C inhibitor ... (2005) Hepsin activates pro-hepatocyte growthfactor and is inhibited by hepatocyte growth factoractivator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett579, 1945–1950.19 Itoh H, Naganuma S, Takeda ... single-chain and two-chain forms of HGF, giving positive bands at 92 and 62 kDa, respec-tively. By scanning of the 92 and 62 kDa bands,the ratio of the single-chain form (inactive) to thetwo-chain...
- 7
- 502
- 0
Báo cáo khoa học: The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 doc
... regulation of rapid recycling from early endosomes [16,17]. Second,Rabaptin-5 can participate in balancing and coordina-tion of endo- and exocytosis through interaction withRabphilin, a regulator of ... effector but unlike Rabaptin-5, does notinteract with the Rab4, presumably due to a disruptedRab4 binding site, and is thus unlikely to provide a link to a Rab4-positive domain. It is tempting to ... eardomains of c1-adaptin, a subunit of the AP-1 adaptorcomplex of clathrin-coated vesicles derived fromtrans-Golgi network (TGN) [20], and GGAs, a family of Arf-dependent clathrin adaptors...
- 10
- 411
- 0
Báo cáo khoa học: Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus docx
... and colleagues, who used a large library of siRNA and inhibitors to interfere with known factors of endocyto-sis. Furthermore, they found that uptake of HPV16does not occur via micropinocytosis ... the affinity of capsids to HSPG or resultsin the exposure of sites required for handover to a putative non-HSPG uptake receptor, which then triggers endocytosis.HPV entry M. Sapp and M. Bienkowska-Haba7208 ... clathrin- and caveolae-independent internalization of HPV16 pseudovirions inHeLa and HEK 293TT cells [60]. Entry and infectionwas resistant to combined siRNA-mediated down-reg-ulation of caveolin-1...
- 11
- 511
- 0
Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx
... interaction of the aNH3+ of SerB1 with the oxyanion and with the side chain of ABFig. 2. Optimized structures of the TI of hydrolysis of acetanilide by QM calculationsat the AM1 level (A) and of N,2-diphenyl-acetamide ... group nitrogen and the main chain carbonyl of GlnB23 leads to theformation of a TS similar to TS2b. The subsequentprotonation of the nucleofuge becomes the rate-limit-ing step of enzyme acylation. ... replaced with acarbon atom. One of the two oxygen atoms was trans-formed into O), and the other into nitrogen; thus, the twodouble S = O bonds were replaced by C–O) and C–Nbonds. The leaving...
- 10
- 425
- 0
Báo cáo y học: "Do we need a critical care ultrasound certification program? Implications from an Australian medical-legal perspective"
... meaning to include anybody that the person may have a professional relationship with. In the case of a doctor-patient relation-ship, the patient is the doctor’s ‘neighbour’ and the doctor must ... patients. Similar to contractual duty, there is a duty on the doctor’s part to exercise reasonable care and skill in the provision of advice and treatment, and a duty to warn the patient of any material ... 1).Standard of care e requisite standard of care is reasonable skills and care reasonably expected of a practitioner with the same standing. e standard of care is diff erent in cases of diagnosis...
- 6
- 714
- 0
Báo cáo y học: "Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome"
... Tokuoka 2, Shigeharu Takagi 3 1. Department of Neurology, Tokai University Tokyo Hospital; 2. Department of Neurology, Tokai University Hachioji Hospital; 3. Department of Neurology, Tokai ... combination of antiplatelet and an-ticoagulation therapy (target INR: 2.0-3.0; mean 2.4±0.3) for the secondary prevention of stroke according to a double-blind protocol. There was no significant difference ... endothelial function, and although the effect may be dose-dependent, the dose of 100 mg may be sufficient to improve endothelial function. There are some important limitations to be con-sidered....
- 4
- 601
- 0
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... phenotype of XLA and thepotential of BTK and ITK inhibitorsThe outcome of defective BTK signaling in humanshas been described previously in detail [26,27], and therefore we will only review this topic ... binding and mutation to tryptophan most probably causes instability of theSH2 domain. Thus, these patients had undetectablelevels of ITK protein despite normal levels of mRNA.Consistent with ... showingthat the PH–TH domain differences between BTK–SYK and ITK–SYK fusion proteins lead to differential phosphorylation levels of the fusion proteins themselves, as well as the downstream adapterproteins...
- 10
- 926
- 0
Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... activepumping of the agents out of the cells and their pas-sive uptake [10,31] and (b) competition between theactive pumping of the agents out of the cells and theirintracellular binding to receptors and ... accumulation of dyes, and probably certain drugs,in the cytoplasm. On the other hand, high-affinitybinding of these agents to intracellular receptors over-whelms the low levels of ABC transporters ... pres-ence of ATP [25]; thus, the increased uptake of rhoda-mine dyes observed in the presence of NBD-Cl doesnot appear to be due to the inhibition of Pgp. A halfmaximal effect of NBD-Cl was...
- 12
- 651
- 0
Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... ascaleable and inexpensive purification procedure. Ab(1–40) and Ab(1–42)coding sequences together with added ATG codons were cloned directlyinto a Pet vector to facilitate production of Met-Ab(1–40) and ... E22K, E22Q and D23N), and the availability of a rapid and simpleexpression and purification protocol will facilitatelarge-scale investigations of the molecular determinants of aggregation and fibrillation. ... Ab(1–40) and Ab(1–42) synthesized using standard Fmoc chemis-try and isolated by SEC as described above. Thiofla-vin T binds to Ab fibrils and protofibrils [30], and hasbeen extensively used to follow...
- 16
- 691
- 0
Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... formany of the biological effects of aldehydes. The zinc-releasing activity of aldehydes establishes relationships among cellular zinc, the functions of endogenous and xenobiotic aldehydes, and redox ... functions of zinc and MT againstethanol toxicityBoth zinc and MT protect the liver and the heartagainst the toxic effects of ethanol [45–47]. The aboveresults suggest that a critical aspect of the ... before use. Owing to the toxicity of some aldehydes,all stock solutions were prepared in a fume hood. A stocksolution of 4-HNE was prepared from the compoundstored at ) 80 °C and used immediately....
- 11
- 473
- 0
Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM