... concept of StrategyEscalation. Strategy 1, simple infusion of 1st generation, isthe most conservative; Strategies 2 and 3, engraftmentOR 2nd generation, are intermediate in risk; Strategy ... agents, termed Strategy Escalation, that accounts for the molecular and biological features of the modified cells and the methods of their administration. This proposal is offered not as a prescriptive ... as elab-orated in Appendix 2: Future directions. Finally, the for- Figure 1 Safe pathways for Strategy Escalation. Note that all esca-lations are permissible except 0 → 4. Dotted paths are proposed...