... stromal cells leading tothese prometastatic events is critical for the design of anorgan-specific therapy of bone metastasis. The BM colonization of metastatic tumors, both of epithelial and non-epithelial ... common site of occulttrafficking, infiltration and growth of blood-borne cancer cells, and their metastases are a major cause of morbid-ity [2]. Not surprisingly, circulating cancer cells infiltrateBM ... 12, 1987, and NIH guide for the care and use of laboratory animals. NIH publicati on85-23, 1985).Culture of Cancer Cells Murine B16 mel anoma (B16M) cells from the B16F10subline, and human...