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http://www.translational-medicine.com/content/9/1/75
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REVIEW Open Access
The role of mutational analysis of KIT and
PDGFRA in gastrointestinal stromal tumors in a
clinical setting
Alessandra Maleddu
1*
, ... 10555].
doi:10.1186/1479-5876-9-75
Cite this article as: Maleddu et al.: The role of mutational analysis of KIT
and PDGF...
... surround-
ing dual practice are about medical practice generally
rather than dual practice as an isolated activity.
An important aspect of regulation is its potential role in
addressing the type of ... and increasing competition in this market and
undermining individuals' income earning ability.
Another manifestation of these pressures in this market
was the 'e...
... Direc-
torate of Human Resources put in place a national regis-
tration system and created a database that details the
training and background of 24 500 health workers. A
semi-autonomous board was established ... Noormal's approach to achieving the gains made by
the Directorate of Human Resources has been character-
ized by a process of reaching consensus and...
... Masood
1
and
Asrul Akmal Shafie
1
Address:
1
Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia and
2
Department
of Pharmacy, University ... pharmacies because of the isola-
tion and lack of recognition of pharmacists as health care
professionals. The lack of trained personnel and the
resulting lac...
... monitoring and
evaluation) and the same proportion was involved in AFP
surveillance. On the other hand, in Zambia, nurses and
midwives were involved in the full range of functions for
SIAs and AFP ... conceptualized the project and wrote the study pro-
posal, designed the questionnaires and initiated and par-
ticipated in discussions, data analysis and...
... STAT1, STAT3,
and STAT5 pathways.
In clinical trials, IL-21 has shown promising clinical
benefits among patients with melanoma and renal can-
cer. IL-21 may find additional clinical applications ... first line melanoma treatment has
been completed and is awaiting data analysis. CTLA-4
blockade has also been tested in phase II clinical trials
of castrate-resistant prostate...
... 5¢-gagagattt
gctttgcgggttatggatctgc-3¢; mutation K20 1A, 5¢-gttatggatctgct
accgcggctccgatcctaaacg-3¢; mutation K201F, 5¢-ggttatggatctg
ctacttcgctccgatcctaaacgc-3¢; and mutation M45 3A, 5¢-ggacaa
ctttgaatgggcggagggttatattgag-3¢. ... details about the role of different resi-
dues of the aglycone-binding site in the stabilization
of ES
à
and the interdependence between the...
... Renata Piccoli, for
critical reading the manuscript and helpful suggestions;
and to Dr Valeria Cafaro, Aurora Bracale, Antonella
Antignani and Sonia Di Gaetano for preparing some
of the RNase variants ... through rotation of the RNase around its major axis (rotation
angle ‘r’) and variation of the inclination (inclination angle ‘i’) with
respect to the plane of the...
... osmoregulation and sporulation. Isola-
tion and characterization of yeast mutants blocked at various sta-
ges of transport pathways are an invaluable method for
unravelling the molecular details of vacuolar ... syndrome and adipocytokines
Y. Matzuzawa
Department of Internal Medicine and Molecular Science, Graduate
School of Medicine Osaka University, Osaka, Japan
Visceral...