... reducedTXA2production and action in human platelets and HEL cells [22,64]. Taken together, these findings haveled to the proposal that clinically PPARc ligands mayattenuate the synthesis and action of TXA2 and, ... located between )182–175 (data notshown). Hence, to extend these studies, the direct bind-ing of and the specific requirement for both PPARc and RXRa for efficient complex formation with the PPRE ... addition, these data point tofurther differences in the modes of transcriptionalregulation of the individual TPa and TPb isoforms inhumans and imply potentially important physiologicdifferences...