Báo cáo sinh học: "Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies" docx
Báo cáo sinh học: "Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies" docx
... study was to develop a pharmacodynamic (PD) marker assay to use in clinical development.The PD marker will determine the effect of GCP inhibitors on GCP enzymatic activity in human skin as measure ... The activity assay provides a simple and directmeasurement of GCP activity from tissue samples easilyassessable in human subjects.AbbreviationsGCP: glutamate carboxypeptidase; NAAG: N-acetyl-aspartyl-glutamate; ... and pig orthologs. Prostate 2008, 68:171-182.doi:10.1186/1479-5876-9-27Cite this article as: Rojas et al.: Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker...
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báo cáo sinh học:" Continuity and change in human resources policies for health: lessons from Brazil" docx
... rapidlydeveloping urban areas. Specific HRH challenges haveincluded attracting and retaining hea lth staff in remoteand/or rural areas, tackling staff mal-distribution andover-specialisation, particularly ... 13This was followed in 1981 by the introduction of the“Programa Larga Escala” which aimed at training basicand elementary health personnel, of whom 50% had noformal training, based on new pedagogical ... improved. In 1990 the physician ratio per 1000 inhabitants was 1.12. In 2007, it was1.74. Another critical factor in achieving staffing growth has been HRH policy making capacity and influence withinthe...
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Báo cáo sinh học: "Radio wave propagation in curved rectangular tunnels at 5.8 GHz for metro applications, simulations and measurements" pot
... literature in a straight arch-shaped tunnel. Then, comparisons with measurements at 5.8 GHz are performed in a curved rectangular tunnel. Finally, a statistical analysis of fast fading is performed ... 15consists in a minimization of the path length, according to the Fermat Principle. Finally, an adaptive IMR has been developed based on the localization of reflection points. Results obtained in a ... efficient radio engineering tools to model the electromagnetic propagation in tunnels for radio planning and network tuning. In this article, we propose an original method based on a Ray Launching...
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báo cáo sinh học:" Health workforce responses to global health initiatives funding: a comparison of Malawi and Zambia" docx
... in January 2007. TheMalawi team incorporated indicators for measuringscale-up into their tools, which had additionalTable 2 Core HIV Indicators in Malawi and ZambiaMalawi ZambiaIndicator2004 ... hospitals.Facility managers reported that workload, which hadbeen a long-standing and worsening problem in Malawi,was being tackled in several ways, including: trainingand rot ating additional ... deliveri ng ARTon top of routine care. The in crease in clinical staff in Malaw i resulted in a decrease in OPD workload in ruraland urban facilities, with a slight increase in semi-urban(district...
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Báo cáo sinh học: "Pro-apoptotic activity of a-bisabolol in preclinical models of primary human acute leukemia cells" pptx
... thedose-response assays for each case are depicted. a- bisabolol plus imatinib mesylate in cells bearingmutated or non-mutated BCR/ABL a- bisabolol was active against Ph+B-ALL cells (24-hourIC50was 46 ... marrow that was frozen in liqu id nitrogen atdiagnosis [13]. In all cases frozen cell samples contained>95% blasts. Cell viability after thawing was always >90%, as assessed by trypan ... data hierarchical clustering analysisTo generate a classification based on a- bisabolol sensitiv-ity, samples were grouped using the complete linkagehierarchical clustering algorithm available...
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Báo cáo sinh học: " Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity" pptx
... protease, and an ubiq-uitin-degrading enzyme in yeast, as well as the identity of a catalytic triad composed of histidine, cysteine, andaspartic acid, I7L has been classified as a cysteine protein-ase. ... A1 0L (P 4a) gene was amplified by polymerase chainreaction using oligonucleotides KH10 (5' CATGCCAT-GGATGATGCCTATTAAGTCAATAGTTACT CTT-3') andKH11 (5'-CCGCTCGAGTTATTCATCATCAAAAGAGACA-GAGTC-3'), ... activity. Effect of Inhibitors on Protease Activity and Characterization as a Cysteine ProteinaseThe in vitro assay allowed us to test the effects of variousprotease inhibitors, as well as specific small...
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Báo cáo y học: "Matrix Metalloproteinase Activity in Pediatric Acute Lung Injur"
... concentration was measured as described by the manufacturer (Bio-Rad, Catalog # 5000112), and separate aliquots were saved at 4° C for immunoblotting and quantitative analysis as outlined below. ... Virus-induced ALI was defined as ALI caused by any viral etiology as determined by a positive rapid viral screen (direct fluorescent antibody for RSV, adenovi-rus, influenza A or B or parainfluenza ... comparisons of MMP and TIMP activi-ties utilizing Sigmastat statistical software (Jandel, CA). A p-value < 0.05 was used to determine statisti-cal significance. As this was an exploratory...
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Tài liệu Báo cáo khoa học: "Mining metalinguistic activity in corpora to create lexical resources using Information Extraction techniques: the MOP system" doc
... ♦ Learning POS tagging & Partial parsing Semantic labeling Database template fillup Mining metalinguistic activity in corpora to create lexical resources using Information Extraction ... templates in our databases. This was done by following different processing routes customized for each pattern using corpus analysis as well as FrameNet data from Name conferral and Name bearing ... information available to an average, idealized speaker). A Metalinguistic Information Database (MID), on the other hand, compiles the real-time data provided by metalan-guage analysis of leading-edge...
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Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc
... P450c1716-ene-synthase and 1 7a- hydroxylase/17,20-lyase activities,we performed transfection assays with increasing amountsof DNA fragments encoding cyt b5and monitored theformation of androstadienol and ... its activity increasing to 15%of preg transformation while the activity of human P450c17increases to 12%. These results show that human andporcine P450c17 have similar catalytic activities and ... DHEA formation from preg isbelow 10%. Increasing P450red up to 0.25 lgcausesadrastic increase of DHEA formation, reaching levels up to50% of preg transformation. On the other hand, increasingamounts...
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Báo cáo Y học: Restoring enzyme activity in nonfunctional low erucic acid Brassica napus fatty acid elongase 1 by a single amino acid substitution pdf
... the mutated gene was expressed in yeast and GCanalysis revealed the presence of very long chain mono-unsaturated fatty acids (VLCMFAs), indicating that theelongase activity was restored in the ... [1-14C]18:1-CoA and malonyl CoA. Theresults of the elongase activity assays are summarized in Table 2. The elongase activity in WS-wt was low as expected, but the activity in the two mutated WS-SDMclones ... 1 (FAE1) clones from higherucic acid (HEA) Brassica napus, Brassica rapa and Bras-sica oleracea, and low erucic acid (LEA) B. napus cv. Westar,were amplified by PCR and expressed in yeast cells...
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