... signaling,leading to beta cell damage and death [26]. To investigate the effect of AL-1 on glucose-induced ROS production in vitro, RIN-m cells were incubated in the presence of highconcentrations of ... Based on thesefindings, we thought that when the animals were admin-istered alloxan, their pancreatic beta cells were damagedbut the limiting threshold for reversibility of decreasedbeta cell ... ani-mals. The reason behind the discrepancy between theseresults is not known at the present time, and needs to befurther investigated.Antioxidants such as N-acetyl-L-cysteine, vitamin C, vita-min...