... connected to the DEC1 E-boxes(Fig. 2), while deletion of the Orange domain ( DEC1DOr-ange) had no effect on the suppressive activity, indicating the importance of t he bHLH region of DEC1. The HXXXXXXXR ... conclude that the basic region, p artic-ularly the conserved A rg65, but not His57, is essential for the suppressive activity of DEC1.Determination of the binding domain of DEC1 to BMAL1 The interaction ... network of the circadian clock system[11,12,14]. In fact, the circadian rhythms of Dec1 and Dec2expression have been shown to be completely disrupted in the SCN a nd some o ther tissues of Clock/Clock...