... For example, the change in Tm(DTm) for theATT bulge increased by 3.4 and 1.7 °C in the presence of DDI-1A and DDI-1B, respectively. The increase in DTm for DDI-1A was higher than that for ... degree of flexibility, writhing and the stability of the hairpin formation, are impor-tant in the investigation of DNA slippage phenomena[3,11,12].Among the non-B-form DNA conformations formedby ... triangularprism binding pocket, with its amino sugar anchored in the major groove of the DNA pointing toward the3¢-bulge-flanking base pair.We were interested in small molecules that can selec-tively bind...