... KS lesions consistent with previous reports [12,25] (Fig. 2). Conversely, infection ofHUVEC with the control retrovirus, BABE, failed to inducea spindle cell-like morphology; rather, these culturesmaintained ... production is dependent on the expression ofCOX-2 but not COX-1.Conclusion: Taken together, these results demonstrate that vGPCR induces expression of COX-2 and PGE2 that may mediate the paracrine ... culturesmaintained a cobblestone-like appearance, which is con-sistent with the morphology of uninfected HUVEC. The infection efficiency for both control and vGPCR-express-ing viruses was approximately...