... study the secondary structure of the catalytic domain of PKCfand the effect of its substrate, MgATP, and also tostudy the effect of thermal unfolding in the presenceand the absence of MgATP. ... structure of 282 residues of a total of 344have been solved [19]. The catalytic domain of PKChpossesses a high degree of homology ( 80%) with the catalytic domain of other isoforms of PKC belongingto ... early separation of the branch of the atypical PKCs from other proteinkinases in the evolutionary tree [43].It is, however, striking that, besides the lack of sequence homology, there is remarkable...