... sites.Taken together, these findings suggest that the struc-tural properties of DNA-damaged substrates, whetherintrinsic or the result of protein binding, function in the recruitment of the XPC–hHR23B ... late steps of the process. For example, early in the NER process, RPA assists TFIIH in the opening of the DNA helix around the damage site [36]. Further-more, in the presence of the XPA minimal ... Binding of XPG induces the release of XPC–hHR23B, whereas XPF–ERCC1 triggers exci-sion of the damaged DNA and the release of XPAand TFIIH. Subsequently, the newly formed gap in the DNA is filled by...