... analyzed the potential influences of the CTLA-4 genotype upon the outcome of IFN adjuvanttherapy, on the basis of prior suggestions of the role of certain polymorphisms of the CTLA-4 gene and otherimmunotherapies ... be further explored in other trials of IFN-a2b of the US and European cooperative groups.Our investigation into the association of CLTA-4 poly-morphisms and the results of interferon therapy ... evaluating the association of outcome to the presence of poly morphisms of CTLA-4 (AG 49, CT 60,CT 318, JO 27, JO 30, JO 31), as well as of the most fre-quent haplotypes. The combined effects of HLA-Cw*06,AG...