Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt

... 9:2http://www.translational-medicine.com/content/9/1/2Page 10 of 11RESEA R C H Open AccessInvolvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteinsTonia ... Buonomo et al.: Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins. Journal of Translational Medicine2011 9:2.Submit ... subsequentlyleading to progression of the cell into the S-phase [14].Furthermore, E7 binds to inhibitors of cyclin-dependentkinases (p16, p21), increasing the level of phosphory-lated pRb. In t his way, HPV...

báo cáo hóa học:" Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin" docx

... WYF.Silencing of ABCC2 by siRNA increased the sensitivity of cisplatin in CNE2 without changing the cellular viabilityFigure 3Silencing of ABCC2 by siRNA increased the sensitivity of cisplatin in CNE2 ... analysis. In vitro the accumulation of intracellular cisplatin in these CNE2 cell clones with reduced expression of ABCC2increased markedly, accompanied by increased sensitivity against cisplatin. In ... protein has the capacity to drive cisplatin out of the CNE2 cells.ABCC2 siRNA increased the sensitivity of cisplatin in CNE2 cells without changing the cell viabilityTo assess the cell viability,...

Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf

... 1011 T cells infused. In the lattercase, one is comparing 1011 T cells transiently present by infusion versus 1011 T cells stably present by engraftment. By moderate increments in risk, the ... essay. These concepts were originally presented at the 2nd "Cellular Therapy of Cancer& quot; Symposium of the AT TACK (Adoptive engineered T -cell Targeting to Activate Cancer Killing) ... binding domain fused to the zeta signaling chain of the T cell receptor ("IgTCR")that can redirect T cell killing against antibody-specifiedtargets [1]. The versatility of this platform...

Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

... signals for the development, function and fitness of nTreg cells. Its signaling cascadeis initiated by the binding of IL-2 to its trimeric IL-2 receptor (IL-2R) which consists of the a-chain (IL-2Ra;also ... thatIL-2 signaling was required for the maintenance of the expression of the genes involved in the regulation of cell growth and metabolism [22]. Hence, IL-2 has a criticalrole in the homeostasis ... ivemarker of onset [70-72]. Furthermore, the number of islet-specific CD4+T cells increases in the blood of pre-diabeti c mice in correlation with increased infiltration of pancreas,however,theirrepertoire,unlikeCD8+cells,was...

Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx

... euge-nin, indicating that eugenin is indeed acting throughCCK2receptors.To further investigate the interaction of eugenin withCCK2receptors, we investigated the effect of eugeninon lymphocyte ... asstimulation of the proliferation of lymphocytes, activa-tion of CCK receptors stimulate production of inter-leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The ... HPLC traces of animals in the ﬁrst two weeks of lactation. The fractioncontaining eugenin is indicated by an asterisk in Fig. 2.Two further HPLC separations of the initial eugenin frac-tion...

Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

... dualsubcellular location, depending on the context. In the cytoplasm, hhLIM increases the stability of the actincytoskeleton by promoting bundling of actin ﬁlaments[114]. In the nucleus, hhLIM interacts ... occurring C-terminal 100 kDa fragment of ﬁlamin, interacting with the motor protein dynein,may exert its inhibitory effect by interfering with inter-actions between the N- and C-terminal domains, ... that the RPEL domain of MRTF-A bindsactin more strongly than the RPEL domain of myocar-din, and that the RPEL motif itself is an actin-bindingelement. RPEL1 and RPEL2 of myocardin bind actinweakly...

Báo cáo khoa học: Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth* potx

... does the moth OAT substitute for DAT in dopami-nergic signaling pathways in the moth CNS, and what is the nature of the mechanism that substitutes for OAT in the octopaminergic pathways in the ... TrnDAT in its lack of expression in the abdominal ganglia other than ganglion A1. It remains tobe shown what system for OA uptake functions in the abdominal nerve cord of the caterpillar. The absence ... tosupport the notion that the neuronal octopamine uptakesystem is the main insecticidal target of cocaine [13,38]. Thisnotion was based on the ﬁnding that the Na+-dependentuptake of DA by synaptosomes...

Báo cáo khoa học: Upstream and intronic regulatory sequences interact in the activation of the glutamine synthetase promoter pot

... lesser extent, in hepatoma cells, is clearly mitigated in the context of the entireupstream region, i.e. by the interposition of 1780 bp. Weinterpret the increase in activity of the upstream ... (muscle). The application of the ANOVAtechnique allowed us to segregate the main(intrinsic) activities of the respective elements from the effects of their interactions. Using this approach, the upstream ... result of the latter effect the upstream enhancer increased the inhibitory effect of the middle intron module, but did notsupport the stimulatory effect of the 3¢-intron module in both cell types....

Báo cáo khoa học: Accessory proteins functioning selectively and pleiotropically in the biosynthesis of [NiFe] hydrogenases in Thiocapsa roseopersicina docx

... the processing of the HupL subunit [15]. It is plausible toassume that HynD is involved in the maturation of the HynL protein. Indeed, in the strain harboring the Tn5transposon-inactivated ... HupK protein. Thirty one amino acidresidues in the truncated HupK originated from the N-terminus, 37 aa from the C-terminus of the protein and13 aa came from the multiple cloning site of the pK18mob-sacB ... to the wild type [33]. On the contrary, inactivation of hupK led to the accumulation of the immature form of the inactivehydrogenase subunits in R. leguminosarum [34]. In T. roseo-persicina the...

Báo cáo khoa học: "A Tradeoff between Compositionality and Complexity in the Semantics of Dimensional Adjectives" potx

... the term S in Table 3 (the sum of the lengths of all of the constraints) is proportional to c (the number of constraints), since there are no more than three pa- rameters in each constraint. ... what kinds of relations appear as constraints in the system, and on the order in which constraints are taken off the queue. The results for systems consist- ing exclusively of one of the three ... in this section by examining whether the increase in representational complexity in the transition from Table 1 to Table 2 entails an increase in the com- putational complexity of reasoning...

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