Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot

... asdescribed above. Percent inhibition was determined using the following formula: [(% specific lysis of inhibi-tion by isot ype control) - (% specific lysis of inhibitionby MAb)]/(% specific lysis ... clinical trial of the vaccination for the patients with metastatic melanoma using gp100-derived epitope peptide restricted to HLA-A*2402Toshiyuki Baba1†, Marimo Sato-Matsushita1†, Akira ... panel. The arrowindicates the timing of each vaccine injection. In ELISPOT assay, to evaluate the characteristics of peptide- specific CTLs, PBMCs of the patients were stimulated in vitro with gp100-in4,...

báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx

... chosen for further clinical eval-uation because the toxicity increased with higher doses in the prior phase I/ II clinical trials, whereas there was evi-dence of reproducible immune activation ... the administration of equivalent mixtures of antibody andIL2 [6].EMD 273063 was tested in a phase I clinical trial aimed atevaluating its safety, toxicity and in vivo immunologicaleffects in 33 patients ... maindrawback of IL2 therapy is its toxicity, especially whenadministered at high doses that require hospitalization for therapy. Most patients receiving the FDA-approved highdose IL2 experience reversible...

Báo cáo hóa học: " A pilot clinical trial testing mutant von HippelLindau peptide as a novel immune therapy in metastatic Renal Cell Carcinoma" doc

... mutations inRCC patients provided the potential for developing a novel targeted vaccine for RCC. In this pilot study, we tested the feasibility of vaccinating advanced RCC patients with the corresponding ... prognosis [21,22]. In addition, we andothers have demonstrated in previous clinical trials that vaccination with peptides from different cancers pro-duces specific immunological responses (specific ... RCC.Methods Patients and eligibility criteriaPatient s with locally advanced, recurrent, progressive, or metastatic RCC were enrolled in this pilot trial. All patients enrolled in the trial met the...

Báo cáo hóa học: " Markedly impaired bilateral coordination of gait in post-stroke patients: Is this deficit distinct from asymmetry? A cohort study" ppt

... recruited from a local fitness center.Inclusion criteria for the patients were: i) a stroke with aMotricity Index score of the paretic leg <100; i i) timesince stroke: ≥ 1 month; iii) ability ... metric for assessing the bilat-eral coordination of gait (PCI) have the potential toenhance the quantitative monitoring of symptoms and the setting of rehabilitation goals in stroke patients. AcknowledgementsThis ... gait deficits and in the selection andmonitoring of rehabilit ation strategies so that they canbe tailored to the particular needs of a patient.ConclusionsIn summary, this initial investigation...

báo cáo hóa học: "Self-adaptive robot training of stroke survivors for continuous tracking movements" pdf

... time assistive (it f acilitates the acquisition of the target) and in formative (it lets the subject know, in real-time, where the target is also in the absence of vision). For slightly impaired ... possibility, for the studied population of patients, because they immediately adapted to the experimental setup in the initial familiarization phase and answered in a positive wa y to a specific ... range of movement directions that are implicitly trained. The sta-bilizing effect of alternating visi on/novision trials,already found in previous studies, is further confirmed,emphasizing the...

báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot

... progressive disease (Fig. 4B, p= 0.0206).DiscussionThis study established the safety and feasibility of com-bining vaccination with MVA expressing 5T4 and high-dose IL-2 in patients with metastatic ... regulatory ratio in future clinical trials.In summary, this study provides safety and feasibility datasupporting the combination of MVA-5T4 vaccine and IL-2 for patients with metastatic RCC. The treatment ... dataand the final responsibility to submit for publication.ResultsPatient characteristicsTwenty five patients were enrolled in the trial andincluded in the ITT population. One patient withdrewfrom...

báo cáo hóa học:" Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer" pptx

... could be clinicallyuseful; however, the utility of the evaluation of HMGB1over-expression in tissue is somewhat limited because of the relatively higher-risk, invasiveness and high cost of the procedures ... 0.05). The HMGB1 level was significantly cor-related with stage by UICC-TNM classification except for stage IV.Evaluation of the sensitivity and specificity of HMGB1 compared to CEA for the diagnosis ... progression of GC. Although the meas-urement of HMGB1 activity in tissues is clinically impor-tant, this method of biomarker analysis is somewhatlimited because the measurement of biomarker activity...

báo cáo hóa học:" KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells" potx

... toPaclitaxel in Type I EOC cells. This suggests the impor-tance of identifying the molecular phenotype of the tumorprior to the initiation of therapy.ConclusionAdministration of Paclitaxel to patients ... patients. ARRY-520 is an inhibitor of the mitotic kinesin, KSP. KSPinhibition prevents bipolar spindle formation leading tomitotic arrest and cell death [6]. In studies comparingARRY-520 with some of the ... since it may enhance tumorgrowth. Therefore, the identification of potential newtherapies for this specific cell population would be bene-ficial for the treatment of ovarian cancer patients. ARRY-520...

Báo cáo hóa học: " HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future" pdf

... L2-neutralizing epitope was inserted on the surfaces of VLPs increasing the titers of neutralizing antibodies approximately 10-fold[60]. A synthetic L2 lipopeptide, in which the cross-neu-tralizing ... capable of mimicking the natural virus and eliciting high-titers of virus neutra-lizing antibodies. The L1 gene from the viral genomewas sub-cloned in microorganisms, such as yeast (for quadrivalent ... to the following issues:1. the risk of HPV-infection remains as long aswomen remain sexually active (at least 70-80% of risk during their lifetime); the rate of prevalence andincidence of high-risk...

Báo cáo khoa học: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand pdf

... activin receptor type I. In the absence of the carbohydrate moiety, activin receptor type I- mediated signaling of BMP-6is totally diminished. Thus, ﬂexibility within the binding epitope of BMP-6and ... inactive in these cells, probably due to its lack of binding to ActR -I. (B) Signaling of BMP-6 and BMP-7 via ActR -I is shown in the inhibition of proliferation in the myeloma cell line INA6, which ... from the dose dependency of equilibrium bind-ing.bKD(kin) as deduced from the association and dissociationrates of the interaction; analysis of dose dependency of equilibriumbinding yields...

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