Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt
... this article as: Sun et al.: Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. Journal of Translational ... Tracking of BrdU-labeled neural stem cells at passage six in the ischemic brain of rat having undergone cell therapy for fourweeks. A: a representative coronal section of a transplanted rat ... both the NSCcultures and the CSF of the rats. The immunochemical staining for MHC in brain sections and the enzyme-linkedimmunosorbent assay of CSF were carried out in sham-operated rats and rats...
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Báo cáo khoa học: Modulation of the Arabidopsis KAT1 channel by an activator of protein kinase C in Xenopus laevis oocytes potx
... activation. (A) Change in the current amplitudes of the quintuple KAT1 mutantKAT1-T30 8A- S31 2A- S58 9A- S59 0A- S64 1A after PMA application. The characteristics of WT KAT1 in the presence and absence of PMA ... kinase (AAPK ⁄ ABRkinase) from Vicia faba has been found to be present in guard cells and to control stomatal response toABA [13–15]. In an in vitro phosphorylation assay, the Vicia AAPK ⁄ ABR ... Yoshida R, Umezawa T, Mizoguchi T, Takahashi S,Takahashi F & Shinozaki K (2006) The regulatorydomain of SRK2E ⁄ OST1 ⁄ SnRK2.6 interacts with ABI1and integrates abscisic acid (ABA) and osmotic...
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Tài liệu Báo cáo khoa học: Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx
... flavin–phenolinteraction. By analyzing the crystal structure of peaFNR, it was deduced that Y308 is constrained against the isoalloxazine in an unfavorable conformationalarrangement by the in uence of amino ... (5¢-GTAATCTATCTACAGAATACAGGAGGGTGATA-3¢) as primers and plas-mid pCV105 [63] as template. In addition, oligonucleotidesFNRup1 (5¢-AACAAGTTCAAACCTAAGGAACCATACG-3¢) and FNRC266Llw (5¢-CCTTTCAGTCCCAACATGTAGACAAAAGTGTTGTC-3¢) ... orientations are also estab-lished, including one in which the interacting rings areoffset and stacked near-planar, and arrangements of face-to-face stacked aromatic rings [42]. By analyzing the...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
... cross-linked interfacial peptides. The N-terminus of PRis indicated (N). The four-stranded b sheet formed by amino-acidresidues at the N- and C-termini of PR is a major binding determinant in the formation ... (p51). The p51 subunit is produced during viral assembly and matur-ation via HIV-1 protease-mediated cleavage of the C-terminal (RNase H) domain of a p66 subunit [31]. A fascinating feature of the ... protein (cI)that binds to its operator (kPR) as a homodimer. The C-terminal dimerization domain of cI can be replaced by another protein that homodimerizes, in this instance aninactive variant...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
... was calculated by summing the infarcted area (unstained) of the eight sections and multi-plying by the interval thickness between sections [60].Analysis of the endocannabinoid system For analysis ... and incu-bated in TTC, which stains viable tissue red but not infarcted areas (C). The infarct volume was calculated by summing the infarcted area of the eight sections (A) and multiplying by ... detected after MCAo,are instrumental for its modulation by estrogen. The modulation of the endocannabinoid system by E2 in the ischemic striatum seems to involve the activa-tion of intracellular...
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Báo cáo khoa học: Stability of the major allergen Brazil nut 2S albumin (Ber e 1) to physiologically relevant in vitro gastrointestinal digestion doc
... corresponding to the ‘large fragment’observed after phase 1 digestion remained (Fig. 5A) .This peak decreased in area and broadened owing to the formation of a range of new fragments as digestionadvanced ... from the large subunit, suggesting that the large chain wasmore resistant to proteolytic attack than the smallchain. The fact that 2S albumin digestion was notaffected by preheating at 100 ... v) in 55 min. The HPLC column temperature was maintained at25 °C and the autoinjector at 4 °C. The 1 mLÆmin)1mobilephase flow exiting the HPLC column was split by using anASI 600 fixed ratio...
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báo cáo hóa học:" Summary of the primer on tumor immunology and the biological therapy of cancer" ppt
... withmonthly administration, and can be alleviated by spacingout treatments. The critical questions for further clinicaldevelopment of anti-CTLA-4 to be answered are: the mechanisms involved in the anti-tumor ... therapies; 4. assess cytokine biology and the role of cytokines in cancer therapy; and 5. evaluate the founda-tion and methods for clinical trials of biologic/immuno-logic therapies.Authors' ... processes. The ligation of VEGFR-2 by the majority of VEGF isoforms triggers the proliferation,migration and survival of endothelial cells, which in tumors form the framework of immature new neoplasticvessels....
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báo cáo hóa học:" Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments" pdf
... not separated into stages 4 and 4S since 4S is for infantsINSS (International Neuroblastoma Staging System) according to Simpson and Gaze [27] at autopsyJournal of Translational Medicine 2009, ... with datainterpretation and drafting of the manuscript written by DF and FA. EL and MS provided input in writing of the manuscript. All authors read and approved the manu-script.Additional materialAcknowledgementsBarbro ... variability has partlybeen explained by variations of hepatic and intestinalCYP 3A4 activity, an enzyme important for metabolizingcyanoguanidines such as CHS 828 [19,43]. Another expla-nation for this...
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báo cáo hóa học:" Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model" docx
... 4Immunohistochemical stainings of a keratome biopsy before (A, B and C) transplantation and after (D, E and F) transplantation and treatment in the psoriasis xenograft SCID mouse. Before transplantation the ... H and K) and Daivobet® (C, F, I and L) in the psoriasis plaque assay. A- C: Masson-Trichrome (MT) staining showing epidermal hyperplasia. D-F: Proliferation of keratinocytes in stratum basale ... method for obtaining early clinical"proof -of- concept" for comparing several treatments and for exploring the mechanism of action of topical anti-pso-riatic treatments in the relevant patient...
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Báo cáo hóa học: " Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032" potx
... provided the material for research; RH, in charge of analyzing tumor specimens andparticipated in writing the manuscript. All authors have read and approved the final manuscript.Competing interests The ... celldetachment and motility in metastatic melanoma cellsand enhancing cell proliferation in primary melanomascarrying NRAS Q61L mutations. These paradoxicaleffects highlight the importance of tailoring ... literature,indicate that the incidence of BRAF V600K mutations in melanoma patients appears to be higher than is com-monly assumed. It can be present in up to 30% of patients bearing BRAF V600...
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